Methodology

 

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The 1Source Potential Risk Index™(PRI) scale for both Ingredients and Products:

 


 

Assessment criteria of our Potential Risk Index ™ (PRI):

  • From the intrinsic chemical properties of the ingredients (LD50, GHS, PubChem data, etc.)

  • From scientifically peer-reviewed papers (MESH, PubMed, etc.)

  • From reputable gov organizations (EU CosIng, US GRAS, FDA, UN WHO, etc.)

  • From manual vetting (company philosophies, sourcing, manufacturing & processing practices, etc.)

  • Appling the 1Source proprietary PRI calculation formula

 

References:

International:

ASTM International Resin Identification Coding System (Plastic Codes):

https://www.astm.org/COMMIT/d7611.pdf

 

GHS on Prolonged (p201 of doc, 89/104 of PDF): http://www.unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev07/English/03e_part3.pdf

 

Globally Harmonized System of Classification and Labelling of Chemicals (GHS): https://www.unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev04/English/ST-SG-AC10-30-Rev4e.pdf

 

International Agency for Research on Cancer (IARC) Methodology: http://www.iarc.fr/en/publications/pdfs-online/epi/cancerepi/index.php

http://www.iarc.fr/en/publications/pdfs-online/epi/cancerepi/CancerEpi.pdf

 

Japan on BHA/BHT:

http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/pages/list-desin.add-x


 

Europe:

Approved E-numbers: https://www.food.gov.uk/science/additives/enumberlist

 

CMR Category Carcinogens: http://www.chemsafetypro.com/Topics/Restriction/REACH_annex_xvii_restriction_CMR_substance_1A_1B.html

 

Cosmetic ingredients database: http://ec.europa.eu/growth/sectors/cosmetics/cosing_en

 

ECHA on naming & labeling convention (p119 of doc, 119/127 of PDF): https://echa.europa.eu/documents/10162/23036412/substance_id_en.pdf/ee696bad-49f6-4fec-b8b7-2c3706113c7d  (Follow <80% and >=10% principle for multi-consituent substances)

 

EU on Triclosan: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_054.pdf

 

European Chemicals Agency (ECHA): https://echa.europa.eu/information-on-chemicals

 

 

North America:

Canada’s List of Ingredients that are Prohibited for Use in Cosmetic Products:

https://www.canada.ca/en/health-canada/services/consumer-product-safety/cosmetics/cosmetic-ingredient-hotlist-prohibited-restricted-ingredients/hotlist.html

 

Canada’s Natural Ingredients List:

http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredsReq.do?srchRchTxt=&srchRchRole=-1&mthd=Search&lang=eng

 

Comparative Toxicogenomic Database (CTD): http://ctdbase.org/;jsessionid=58CC7CA7AF2BB8C8016BD3DF9B6EC1AC

 

DSHEA List (Old Dietary Ingredients List until the FDA relinquished control over supplements due to the DSHEA 1994):

https://www.unpa.com/Portals/0/Documents/News/UNPA_ODI_List%207-23-08.pdf

FDA Approved Sunscreen Ingredients:

https://www.skincancer.org/prevention/uva-and-uvb

 

FDA Food Additive Status List:

https://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/ucm091048.htm

 

FDA on Aspartame:

https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm208580.htm

 

FDA on Triclosan: https://www.federalregister.gov/documents/2016/09/06/2016-21337/safety-and-effectiveness-of-consumer-antiseptics-topical-antimicrobial-drug-products-for

 

Generally Regarded As Safe Database (GRAS): https://www.accessdata.fda.gov/scripts/fdcc/?set=SCOGS

 

Gurvey & Berry: http://www.gurveyberry.com/products/

 

Household Products Database: https://householdproducts.nlm.nih.gov/cgi-bin/household/list?tbl=TblChemicals&alpha=A

 

NCBI on BHT:

https://www.ncbi.nlm.nih.gov/pubmed/12396675

 

NTP on BHT:

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butylatedhydroxyanisole.pdf

 

PubChem: https://pubchem.ncbi.nlm.nih.gov/

 

PubMed: https://www.ncbi.nlm.nih.gov/pubmed/

 

Sigma-Aldrich Merck: https://www.sigmaaldrich.com/